The American Society for 

Reproductive Immunology 

wednesday, june 12

 12:00 PM - 6:00 PM Registration  Center Concourse
 1:00 PM - 3:00 PM Executive Council Meeting  Pearl Room
 5:00 PM -  5:10 PM Welcome Remarks

Gil Mor, MD PhD, Wayne State University

Karen Racicot, PhD, Michigan State University

Richard Leach, MD, Michigan State University

 Pantlind Ballroom
 5:10 PM - 6:00 PM

PL01: Keynote Lecture

Chairs: Gil Mor, MD PhD, Wayne State University, Karen Racicot, PhD, Michigan State University

Judith Van de Water, PhD

UC Davis MIND Institute 

UC Davis Center for Children’s Environmental Health

Professor, Department of Internal Medicine, UC Davis School of Medicine

 Pantlind Ballroom
 6:00 PM - 7:30 PM

WELCOME RECEPTION  -  Cocktails & Hors D'oeuvres

 Center Concourse

thursday, june 13

 7:00 AM - 8:00 AM BREAKFAST  Center Concourse
 7:30 AM - 5:00 PM Registration  Center Concourse
 8:00 AM - 10:00 AM PL02: President's Session  Ambassador Ballroom

Welcoming Remarks and Introduction

Gil Mor, MD PhD, Yale University


President’s Distinguished Lecture

Tippi MacKenzie, MD

University of California, San Francisco


ASRI Award Lecture - Irina Burd, MD, PhD, Johns Hopkins Medical Institute


Braverman Award Lecture - Jun Lei, PhDJohns Hopkins University

Immunomodulatory therapies for prevention of ZIKV congenital infection

10:00 AM - 10:30 AM COFFEE BREAK  Center Concourse
10:30 AM - 12:30 PM S-01: Host-Pathogen Interactions in the Reproductive Tract 

Chair: Ja-Young Kwon, MD, PhD, Yonsei University

 Ambassador East

S01.1 David Aronoff, MD, Vanderbilt University

Macrophages in host defense against Group B streptococcal chorioamnionitis


S01.2 - Nabila Jabrane-Ferrat, PhD, CPTP-INSERM

Viral pathogenesis at the maternal-fetal interface

11:30-12:00  S01.3 -  Ja-Young Kwon, MD, PhD, Yonsei University

Relevance of placental type I interferon in the regulation of host-pathogen interactions


OR01 - Ryan Doster, PhD, Vanderbilt University Medical Center

The role of Streptococcus agalactiae cadD in metal efflux, survival in macrophages, and ascending vaginal infection during pregnancy


OR02 - Rebecca Casazza, PhD, University of North Carolina

Interferon lambda signals to maternal tissues to limit Zika virus transplacental transmission in mice

10:30 AM - 12:30 PM S-02: Contribution of Maternal Immune System to the Etiology of Pre-Eclamsia

Chair: Charles H. Graham, PhD, Queen's University, Virginie Gaudreault, Universite de Montreal

 Ambassador West

S02.1 - Stephan Renaud, PhD, University of Western Ontario

Natural killer cells: friends, foes, and implications for preeclampsia

11:00-11:30  S02.2 - Lawrence Chamley, PhD, University of Auckland 

Antiphospholipid antibodies and dangerous extracellular vesicles from the syncytiotrophoblast


S02.3 - Sylvie Girard, PhD, Universite de Montreal

Maternal Immune Mediated Endothelial Activation in Preeclampsia


OR03 - Cyntia Duval, PhD, Universite de Montreal

Altered transcriptome profiles in placentas from complicated pregnancies in association with adverse neonatal outcomes


OR04 - Caroline Dunk, PhD, Lunenfeld Tanenbaum Research Institute

The STOX1 genotype associated with severe preeclampsia negatively affects extravillous trophoblast-leukocyte mediated uterovascular remodelling in early pregnancy

12:30 PM - 2:00 PM LUNCH BREAK  
2:00 PM - 4:30 PM S-03: Perinatal Influences on Neurodevelopment  

Chairs: Keith English, PhD, Michigan State University & Richard Leach, MD, Michigan State University

 Ambassador East

S03.1 - Suresh Boppana, MD, University of Alabama, Birmingham

Congenital CMV Infection and Neurologic Morbidity

2:30-3:00  S03.2 - Daniel Campbell, PhD, Michigan State University

Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression


S03.3 - Nigel Paneth, MD, Michigan State University

Inflammation-related proteins in the first weeks of life and neurodevelopment in extremely low gestational age newborns (ELGANs)

3:30-4:00  S03.4 - Charles Wood, PhD, University of Florida

Exposure of the Fetus to Bacteria in Pregnancy: Physiological Exposure of the Fetus to Antigens in the Maternal Environment?

4:00-4:30  Moderated Panel Discussion  
2:00 PM - 4:30 PM S-04: Pros and Cons of Immune-Modulatory Agent Use in Reproductive Medicine

Chairs: Abey Eapen, PhD, Univ. of Iowa & Soo Hyun Ahn, PhD, Michigan State Univ.

 Ambassador West
2:00-2:30  S04.1 - Joanne Kwak-Kim, MD, Rosalind Franklin University

Intravenous immunoglobulin G infusion treatment for women with recurrent pregnancy losses and repeated implantation failures

2:30-3:00  S04.2 - Koji Nakagawa, MD,  Sugiyama Clinic Shinjuku

Immunosuppressive treatment with tacrolimus improves reproductive outcome of women with repeated implantation failures who have elevated Th1/Th2 cell ratios

3:00-3:30  S04.3 - Svetlana Dambaeva, MD, PhD, Rosalind Franklin University

Natural Killer cell education and unexplained infertility

3:30-4:00  S04.4 - Nathalie Ledee, MD, INSERM

Personalization of assisted reproductive treatments in function of the endometrial immune profile

4:00-4:30  Moderated Panel Discussion   
5:00 PM - 7:00 PM

Grand Rapids Brewery Tours (optional group event)

 Meet in hotel lobby

7:00 PM - 9:00 PMAJRI Editorial Board Meeting Grandview


friday, june 14

 7:00 AM - 8:00 AM BREAKFAST  Center Concourse
 7:30 AM - 5:00 PM Registration  Center Concourse
 8:00 AM - 9:45 AM

PL03: Meeting Chair’s Session

Evolutionary Role of the Immune System in Reproduction

Chairs: Karen Racicot, PhD, Michigan State University, Troy Ott, PhD, Penn State University

 Ambassador Ballroom

PL03.1 - Gunter Wagner, PhD, Yale University

Evolutionary modification of the inflammatory reaction at the fetal-maternal interface


PL03.2 - Thomas Spencer, PhD, University of Missouri

The evolution of the placenta

9:00-9:30  PL03.3 - Douglas Antczak, VMD, PhD, Cornell University

Co-option of immune system molecules by the placenta

9:30-9:45  Moderated Panel Discussion  
 9:45 AM -10:00 AM  COFFEE BREAK  Center Concourse
10:00 AM - 12:00 PM S-05: Immune System Role in Pathogenesis of Endometriosis

Chair: Kaori Koga, MD, University of Tokyo & Yosuke Ono, PhD, Tonami General Hospital

 Ambassador East
 10:00-10:30  S05.1 - Osama Yoshino, PhD, Toyama University

The involvement of Damage-associated molecular patterns (DAMPs) and macrophages in the etiology of endometriosis

10:30-11:00  S05.2 - Chandrakant Tayade, PhDQueen's University

Immune dysfunction in endometriosis


S05.3 - Kaori Koga, MD, University of Tokyo

Peritoneal Immune Cells in the Pathogenesis of Endometriosis


OR05 - Yosuke Ono, PhD, University of Toyama, Japan

The role of M2 macrophage in endometriosis


OR06 - Nhung Le, PhD, Southern Illinois University

Alteration of Microbial Communities and Immune Populations in Patients with Endometriosis

10:00 AM - 12:00 PM S-06: The Impact of the Maternal Microbiome on Pregnancy and Fetal Outcomes

Chairs: Andrea Braundmeier-Fleming, PhD, Southern Illinois University

 Ambassador West

S06.1 - Andrea Braundmeier-Fleming, PhD, Southern Illinois University

The Impact of Maternal Inflammation on Preterm Birth

10:30-11:00  S06.2 - Indira Mysorekar, PhD, Washington University

Ralstonia insidiosa: Introducing a bona fide microbial resident in the placenta

11:00-11:30  S06.3 - Kevin Theis, PhD, Wayne State University

Does the human placenta delivered at term have a microbiota?


OR07 - Haley Dupont, PhD, McMaster University

Examining the effect of the vaginal microenvironment on growth and colonization of Lactobacillus species


OR08 - Ramakrishna Kommagani, PhD, Washington University St. Louis

The gut microbiota drives endometriosis by promoting inflammation

 12:00 PM - 1:00 PM


 12:00 PM - 1:00 PM

MENTOR/TRAINEE LUNCH    Click for Details

Chair:  Sylvie Girard, PhD, Universite de Montreal

 Gerald Ford Ballroom
 1:00 PM - 3:00 PM S-07: Immune Function at the Fetal Membranes

Chairs: Vikki Abrahams, PhD, Yale University, Mancy Tong, PhD, Yale University

 Ambassador East

S07.1 - Mancy Tong, PhD, Yale University

Mechanisms of Fetal Membrane Induced Neutrophil Activation and Extracellular Trap Release


S07.2 - Nardhy Gomez-Lopez, PhD, Wayne State University

Intra-amniotic inflammasome activation in preterm labor

S07.3 - Ramkumar Menon, PhD, University of Texas Medical Branch

Fetal, not maternal, Inflammatory Response Determines LPS Induced Birth Outcomes in Murine Models

OR09 - Jennifer Gaddy, PhD, Vanderbilt University Medical Center

The role of zinc homeostasis in Group B Streptococcus biofilm formation in vitro and in an instrumented fetal membrane on a chip


OR10 - Kenichiro Motomura, PhD, Wayne State University

Diverse host-pathogen interactions in intra-amniotic infections associated with genital mycoplasmas

 1:00 PM - 3:00 PM S-08: Reproductive Immunology in the Male

Chairs: Indira Mysorekar, PhD, Washington University & Elaine Parker, PhD, Washington University

 Ambassador West
 1:00-1:30  S08.1 - Kaylan Bruner-Tran, PhD, Vanderbilt University

Transgenerational Consequences of Developmental Toxicant Exposure of the Male

1:30-2:00  S08.2 - John Bromfield, PhD, University of Florida

Seminal plasma is more than a swimming pool for sperm: the potential for semen components to contribute to pregnancy outcomes

2:00-2:30  S08.3 - Mark Peter Hedger, PhD, Hudson Institute

Current concepts in male reproductive immunophysiology - immunoregulation, inflammation and infertility


OR11 - Yongning Lu, PhD, Fudan University

Uropathogenic E. Coli Infection compromises blood-testis barrier by disturbing mTORc1-mTORc2 balance


OR12 - Aihua Liao, PhD, Huazhong University of Science and Technology

Expression and localization of PD-1 and PD-L1 in mouse testes

 3:00 PM - 3:30 PM COFFEE BREAK  
 3:30 PM - 5:30 PM S-09: Role of Maternal and Fetal Immune Systems in Pregnancy Outcomes

Chair: Ana Zenclussen, PhD, Otto-von-Guericke University & Anne Schumacher, PhDOtto-von-Guericke University

 Ambassador East
3:30-4:00  S09.1 - Joanna Halkias, MD, UC San Francisco

The human fetal intestine is enriched for pro-inflammatory PLZF+ CD4+ T cells associated with preterm birth

 4:00-4:30  S09.2 - Lachlan Moldenhauer, PhDUniversity of Adelaide

Mating induces expansion, phenotypic modulation and epigenetic alteration in Foxp3 within the thymus-derived regulatory T cells in mice

4:30-5:00  S09.3 Ana Zenclussen, PhD, Otto-von-Guericke University

Feto-maternal communication during pregnancy


OR13 - Ruth Marian Guzman-Genuino, PhD, University of South Australia

Maternal B cells contribute to the regulation of inflammatory processes required for successful implantation


OR14 - Na Shin, PhD, Johns Hopkins Medical Institute

Serum amyloid A may provide a link between maternal inflammation and placental dysfunction

 3:30 PM - 5:30 PM

S-10: Immune Modulation of Reproductive Malignancies

Chairs: Animesh Barua, PhD, Rush University & Ronald Chandler, PhD, Michigan State University

 Ambassador West
 3:30-4:00  S10.1 - Benjamin Tsang, PhD, University of Ottawa

In Search of Early Diagnosis and Immunotherapeutic Strategy for Chemoresistant Ovarian Cancer in the Era of Personalized Cancer Medicine

4:00-4:30  S10.2 - Ronald Chandler, PhD, Michigan State University

Mechanistic role of SWI/SNF chromatin remodeling in inflammation-associated gynecologic cancers

4:30-5:00  S10.3 - Adrian Erlebacher, MD, PhD, Univ. California San Francisco

Neutrophils as hypoxia-regulated anti-tumor effectors in endometrial cancer


OR15 - Alpana Sharma, PhD, All India Institute of Medical Sciences

Clinical significance of autophagy related molecules in liquid biopsy of cervical cancer


OR16 - Animesh Barua, PhD, Rush University

Ovarian tumor-induced suppression of anti-tumor function of NK cells and strategies for its prevention


saturday, june 15

 7:00 AM - 8:00 AM BREAKFAST  Center Concourse
 7:30 AM - 5:00 PM Registration  Center Concourse
 8:00 AM - 9:30 AM PL04: Gusdon Award Session  Ambassador Ballroom

G01 - Sean Nguyen. PhD, Michigan State University

Trafficking of placental extracellular vesicles in murine pregnancy

 8:15-8:30  G02 - Lea Lentz, PhD, Otto-von-Guericke University

Human chorionic gonadotropin favors fetal tolerance by regulating the Treg/TH17 balance and promoting anti-inflammatory T cell responses in mice


G03 - Qian Chen, PhD, Centre of Pathophysiology Toulouse Purpan, France

Zika virus subverts the placental lipidome to induce inflammation


G04 - Ramtin Ghasemi, PhD, McMaster University

The effect of estradiol on B cell responses against herpes simplex virus type 2


G05 - Alison Eastman, PhD, Vanderbilt University Medical Center

Decidual Stromal Cells and Cytotrophoblasts Synergize to Dampen and Modulate Macrophage Activation in Response to Group B Streptococcus Infection


G06 - Valeria Garcia-Flores, PhD, Wayne State University

Adoptive transfer of in vitro M2-polarized macrophages prevents preterm birth and neonatal mortality

9:30 AM - 11:00 AM PS01: Poster Session  Ambassador Foyer
11:00 AM - 12:30 PM  LUNCH BREAK  on your own
12:30 PM - 2:30 PM S-11:  Sexually Transmitted Infections

Chairs: Charles Wira, PhD, Dartmouth University & Marta Rodriguez Garcia, PhD, Dartmouth University

 Ambassador East
 12:30-1:00 S11.1 - Marta Rodriguez Garcia, PhD, Dartmouth University

Changes in Mucosal Immunity that Influence Susceptibility to HIV-infection before and after Menopause


S11.2 - Caroline Attardo Genco, PhD, Tufts University

Sex as a Variable: Distinct Gonococcal Gene Signatures Expressed During Natural Human Mucosal Infection in Men and Women

S11.3 - Wilbert Derbigny, PhD, Indiana University

TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection


OR17 - Mimi Ghosh, PhD, George Washington University

Stress Response and Immune Dysregulation Following Acute Sexual Trauma Exposure in Women at High Risk of HIV


OR18 - Clare Gyorke, PhD, University of North Carolina

Interleukin-1 alpha drives oviduct pathology by enhancing immune cell recruitment, cell death, and bacterial ascension during Chlamydia muridarum infection

12:30 PM - 2:30 PM

S-12: Tissue-Associated Innate Lymphoid Cell Function During Pregnancy

Chairs: Dorothy Sojka, PhD, Washington University St. Louis & Margaret Petroff, PhD, Michigan State University

 Ambassador West
 12:30-1:00  S12.1 - Binqing Fu, PhD, University of Science and Technology of China

CD49a+ tissue-resident-natural killer cells promote fetal development in early pregnancy

1:00-1:30  S12.2 - Aleksandar Stanic-Kostic, University of Wisconsin

Plastic Fantastic: Transcriptional Malleability and Functional Stability of Decidual Innate Lymphoid Cells

1:30-2:00  S12.3 - Dorothy Sojka, PhD, Washington University St. Louis

Uterine Tissue-Resident NK Cells


OR19 - Huili Yang, PhD, Hospital of Obstetrics and Gynecology, Shanghai

Decidual stromal cells promote the differentiation of CD56brightCD16-NK cells by secreting IL-24 in early pregnancy


OR20 - Boris Dons'koi, PhD, National Academy of Medical Sciences of Ukraine

IvIg treatment neutralizes the negative effect of elevated NK cytotoxicity in IVF

 2:30 PM - 3:00 PM COFFEE BREAK  Ambassador Foyer
 3:00 PM - 5:00 PM

S-13: Placental Immune Function as a Predictor of Maternal and Fetal Health Outcomes 

Chair: Jennifer Gilner, MD, PhD, Duke University & Joanna Halkias, MD, UC San Francisco

 Ambassador East
 3:00-3:30  S13.1 - Thaddeus Golos, PhD, University of Wisconsin-Madison

Non-human primate models of pathogen responses at the maternal-fetal interface

3:30-4:00  S13.2 - Alexandre Bonnin, PhD, University of Southern California

Stress and inflammation effects on the placenta-fetal brain axis: an early neurotransmitter perspective

4:00-4:30  S13.3 - Jennifer Gilner, MD, PhD, Duke University

Deciphering the Reproductive Rosetta Stone: Placental immunology predictions of maternal and fetal health


OR21 - Marie-Eve Brien, PhD, Universite De Montreal-CHU Sainte-Justine

Non-infectious inflammation during pregnancy is associated with fetal growth restriction and altered neurodevelopment

4:45-5:00  OR20 - Meredith Kelleher, PhD, Oregon Health & Science University

Altered fetal hemodynamic status and neuroinflammation in a nonhuman primate model of intrauterine Ureaplasma parvum infection

3:00 PM - 5:00 PM S-14: Role of Maternal Vaccinations in Protecting Against Neonatal Diseases

Chair:  Beth Holder, PhD, Imperial College London & Linda Eckert, PhD, University of Washington

 Ambassador West
 3:00-3:30  S14.1 -  Beth Holder, PhD, Imperial College London

The Impact of Maternal Pertussis Vaccination on the Maternal and Infant Immune System

3:30-4:00  S14.2 - Margaret Ackerman, PhD, Dartmouth College 

Protective antibodies twice removed - prospects for inherited passive immunity

4:00-4:30  S14.3 - Linda Eckert, PhD, University of Washington

Moving Maternal Immunization Forward with Standardized Definitions and Data Collection Tools


OR23 - Mohan Raut, PhD, Dr. Raut's Immunotherapy centre for Prevention of Repeated Miscarriages (ICPRM)

Immunomodulation with lymphocyte immunization therapy (LIT) and other immunomodulators in unexplained recurrent IVF failures - is it worth?


OR24 - Puja Bagri, PhD, McMaster University

Estradiol enhances anti-viral CD4+ tissue-resident memory T cell responses following mucosal HSV-2 immunization

5:00 PM - 6:00 PM Cocktail Reception  East Concourse
6:00 PM - 7:30 PM  Awards Dinner & Closing Remarks  Pantlind Ballroom
7:30 PM - 9:30 PM Entertainment / Dancing  

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